Prof Lesley Jones, Cardiff University School of Medicine, Cardiff, UK
Prof Lesley Jones has a long-standing interest in neurodegeneration, particularly in Huntington’s (HD) and Alzheimer’s disease (AD). She has organised and performed genetic and genomic studies in HD and AD, analysed mouse models of disease and determined the biological mechanisms through which the diseases work, to identify new targets for therapies. In AD her pathway analysis papers highlighted the aetiological contribution of the immune system to AD that now forms a key area of therapeutic research. In HD her leadership in the Genetic Modifiers of HD consortium and in other repeat diseases provide novel avenues for therapeutic exploitation in DNA repair that inform her current research.
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